Key result
Vinyl chloride monomer exposure links to 2 new liver angiosarcoma cases in retired autoclave cleaners.
Case Report (n=2)
No
Continued surveillance of plastic industry workers exposed to vinyl chloride monomer is necessary as new cases of liver angiosarcoma continue to emerge.
Persisting angiosarcoma risk in vinyl chloride-exposed retirees; supports ongoing surveillance but leaves open updated risk thresholds.
In this report of two new cases of liver angiosarcoma (ASL) among plastic industry workers, the authors present the history and perspectives of this problem. The first cases of ASL have been registered since 1974, and in 1984, the European register of angiosarcoma was founded. In this register, 11 cases of ASL and one case of haemangiopericytoma have been registered from Croatia, all from a single plastics plant near Split. Two new cases of ASL (in retired autoclave cleaners, who were exposed to a concentration of 500-1000 ppm vinyl chloride monomer (VCM) during the working process) in the same plant are represented. They were detected with combined techniques of ASL detection, and both are still alive. The diagnoses have been histologically confirmed: one of them was surgically treated with segmental liver resection. The appearance of new cases of ASL confirms the perspective presented in the last report by the same authors.
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Hozo et al. (1997) conducted a case report in Liver angiosarcoma (n=2). Vinyl chloride monomer (VCM) was evaluated on Development of liver angiosarcoma. Exposure to 500-1000 ppm vinyl chloride monomer resulted in two new histologically confirmed cases of liver angiosarcoma among retired autoclave cleaners in Croatia.
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