Key result
Oxidative stress is hypothesized to induce cardiomyocyte apoptosis and subsequent architectural rearrangement, potentially driving the development of myocardial disarray in diabetes.
Why the study?
Does oxidative stress play a role in the development of myocyte disarray in diabetes?
Population
Patients or models with diabetes in which heart muscle apoptosis is evident
Design
Review
Authors
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Hypothesis-generating for oxidative stress in diabetic myocardial disarray; prospective trials needed before clinical adoption.
Does oxidative stress play a role in the development of myocyte disarray in diabetes?
This review proposes a mechanistic link between oxidative stress, cardiomyocyte apoptosis, and the development of myocardial disarray in diabetic cardiomyopathy.
Lasker et al. (2011) conducted a review in Diabetes. Oxidative stress was evaluated. Oxidative stress is hypothesized to induce cardiomyocyte apoptosis and subsequent architectural rearrangement, potentially driving the development of myocardial disarray in diabetes.
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