Key result
Acetylpromazine induced significant increases in arterial diameter (P<0.01) and volumetric flow rate (P<0.05) in the equine metatarsal artery.
p-value: p=<0.01 and <0.05
May enhance equine peripheral perfusion; leaves open clinical translation pending controlled trials.
Heart rate, blood velocity, volumetric blood flow, and arterial diameter for 10 horses given acetylpromazine were determined from measurements of the dorsal metatarsal artery 3 (the great metatarsal artery), using 2-dimensional real-time and gated pulsed Doppler ultrasonography. Acetylpromazine induced significant increases in arterial diameter (P less than 0.01) and volumetric flow rate (P less than 0.05)--all compatible with adrenergic blockade. There was a trend indicating that there was increased blood velocity. Heart rate was unchanged.
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Walker et al. (1986) studied this question. Acetylpromazine was evaluated on Arterial diameter and volumetric flow rate (p=<0.01 and <0.05). Acetylpromazine induced significant increases in arterial diameter (P<0.01) and volumetric flow rate (P<0.05) in the equine metatarsal artery.
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