Key result
The long isoform of the human zinc finger antiviral protein (hZAP-L) is a more potent inhibitor of alphaviruses than the short isoform, and its PARP-like domain triad motif is essential for this activity.
Population
In vitro model using Sindbis virus as a prototype alphavirus to study human zinc finger antiviral protein…
Comparison
hZAP-L, small interfering RNA knockdown of… vs hZAP-S (short isoform) and wild-type hZAP-L
Design
Preclinical
Authors
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Suggests hZAP-L PARP-like domain as antiviral target; leaves open translation to human alphavirus therapy.
The PARP-like domain in the long isoform of the human zinc finger antiviral protein is essential for its antiviral activity against alphaviruses.
Gläsker et al. (2014) studied Alphavirus infection. hZAP-L (long isoform of human zinc finger antiviral protein) vs. hZAP-S (short isoform) and mutated hZAP-L was evaluated on Antiviral activity against alphaviruses (Sindbis virus). The long isoform of the human zinc finger antiviral protein (hZAP-L) is a more potent inhibitor of alphaviruses than the short isoform, and its PARP-like domain triad motif is essential for this activity.
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