Key result
The zinc-finger antiviral protein (ZAP) inhibits viral replication by specifically binding to viral mRNA and recruiting cellular RNA degradation machinery to promote viral mRNA decay.
Design
Review
Authors
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ZAP's antiviral mechanism may guide future host-directed therapies; leaves open clinical translation pending targeted trials.
This article reviews the mechanisms by which the zinc-finger antiviral protein (ZAP) promotes viral mRNA decay.
Zhu et al. (2008) conducted a review in Viral infection. Zinc-finger antiviral protein (ZAP) was evaluated. The zinc-finger antiviral protein (ZAP) inhibits viral replication by specifically binding to viral mRNA and recruiting cellular RNA degradation machinery to promote viral mRNA decay.
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