Key result
In patients with cirrhosis, Ang-(1-7)/Ang II ratios were higher in splanchnic than peripheral circulation (0.52 vs 0.38, P<0.02) and correlated with cardiac output (r=0.66).
Why the study?
Does the relationship between angiotensin-(1-7) and angiotensin II correlate with hemodynamic changes in patients with human liver cirrhosis?
Observational
Does the relationship between angiotensin-(1-7) and angiotensin II correlate with hemodynamic changes in patients with human liver cirrhosis?
Absolute Event Rate: 0.52% vs 0.38%
p-value: p=<0.02
The ratio of Ang-(1-7) to Ang II correlates with cardiac output and systemic vascular resistance, suggesting a role in the hemodynamic changes of human cirrhosis.
Suggests Ang-(1-7)/Ang II involvement in cirrhosis hemodynamics; hypothesis-generating and requires prospective validation before any clinical consideration.
AIM: To measure circulating angiotensins at different stages of human cirrhosis and to further evaluate a possible relationship between renin angiotensin system (RAS) components and hemodynamic changes. METHODS: Patients were allocated into 4 groups: mild-to-moderate liver disease (MLD), advanced liver disease (ALD), patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity (PRA), angiotensin (Ang) I, Ang II, and Ang-(1-7) levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components. RESULTS: PRA and angiotensins were elevated in ALD when compared to MLD and controls (P < 0.05). In contrast, Ang II was significantly reduced in MLD. Ang-(1-7)/Ang II ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang II levels were lower and Ang-(1-7)/Ang II ratios were higher in the splanchnic circulation than in the peripheral circulation (0.52 +/- 0.08 vs 0.38 +/- 0.04, P < 0.02), whereas the peripheral circulating Ang II/Ang I ratio was elevated in comparison to splanchnic levels (0.18 +/- 0.02 vs 0.13 +/- 0.02, P < 0.04). Ang-(1-7)/Ang II ratios positively correlated with cardiac output (r = 0.66) and negatively correlated with systemic vascular resistance (r = -0.70). CONCLUSION: Our findings suggest that the relationship between Ang-(1-7) and Ang II may play a role in the hemodynamic changes of human cirrhosis.
No takes yet. Share an insight, caveat, or question.
Vilas-Boas et al. (2009) conducted an observational in liver cirrhosis. Liver cirrhosis vs. Healthy controls was evaluated on Ang-(1-7)/Ang II ratio in splanchnic vs peripheral circulation during liver transplantation (p=<0.02). In patients with cirrhosis, Ang-(1-7)/Ang II ratios were higher in splanchnic than peripheral circulation (0.52 vs 0.38, P<0.02) and correlated with cardiac output (r=0.66).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: