Key result
Genetics plays an increasingly important role in understanding the mechanisms of atrial fibrillation and guiding its future personalized management.
Why the study?
Despite advances in AF management, large individual differences in treatment responses exist and underlying mechanisms of initiation and perpetuation remain incompletely understood.
Genetics may play a future role in the personalized management of atrial fibrillation by explaining individual differences in treatment response.
May inform future personalized AF strategies; leaves open prospective validation before clinical adoption.
Atrial fibrillation (AF) management has significantly improved during the career of professor Crijns. Research was implemented into guidelines and clinical practice. However, despite advances in AF management, large differences between individual treatment responses still exist and the mechanisms underlying initiation and perpetuation of AF are not completely understood. International collaborations have revealed the genetic contribution to AF and steps towards improving AF management are being made. In this short review, the most important paradigms shifts in the field of AF genetics are recognized and the future role of genetics in personalized management of AF is discussed.
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Rienstra et al. (2020) conducted a review in Atrial fibrillation. Genetics was evaluated. Genetics plays an increasingly important role in understanding the mechanisms of atrial fibrillation and guiding its future personalized management.
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