Key result
Selective whole blood lipoprotein apheresis reduced triglyceride levels by 19% to 35% per session and prevented further relapses of acute pancreatitis in a patient with drug-refractory hypertriglyceridemia.
Why the study?
Does selective whole blood lipoprotein apheresis reduce triglyceride levels and prevent pancreatitis relapses in a patient with drug-refractory hypertriglyceridemia?
Case Report (n=1)
No
Does selective whole blood lipoprotein apheresis reduce triglyceride levels and prevent pancreatitis relapses in a patient with drug-refractory hypertriglyceridemia?
Selective whole blood lipoprotein apheresis is a feasible treatment to lower triglycerides and prevent pancreatitis relapses in patients with drug-refractory hypertriglyceridemia.
May warrant consideration in refractory hypertriglyceridemic pancreatitis; leaves open the need for controlled trials to establish efficacy.
CONTEXT: Severe hypertriglyceridemia is a known cause of acute pancreatitis, and apheresis treatment, most commonly plasmapheresis, has been used to treat patients with drug refractory hypetriglyceridemia for more than 30 years. CASE REPORT: We report a case in which a woman with Crohn's disease and type 2 diabetes mellitus developed recurrent episodes of acute pancreatitis due to extreme hypertriglyceridemia. After the initiation of lipoprotein apheresis from whole blood, a marked reduction of triglyceride and lipoprotein levels was observed. Some inflammatory parameters were increased even if most of the cytokines were not detectable, indicating good biocompatibility of the filter. CONCLUSIONS: Triglyceride levels were lowered after initiating selective lipoprotein apheresis. More importantly, the patient did not experience any relapses of pancreatitis after the treatment was started. Hence this treatment is feasible in drug refractory hypertiglyceridemia, but the treatment concept needs to be tested in additional studies.
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Hovland et al. (2015) conducted a case report in Drug refractory hypertriglyceridemia and recurrent acute pancreatitis (n=1). Selective whole blood lipoprotein apheresis was evaluated on Triglyceride levels and pancreatitis relapses. Selective whole blood lipoprotein apheresis reduced triglyceride levels by 19% to 35% per session and prevented further relapses of acute pancreatitis in a patient with drug-refractory hypertriglyceridemia.
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