Key result
Eel ventricular natriuretic peptide produced similar diuresis and natriuresis to ANP and BNP, but unlike BNP, it did not decrease cardiac output or stroke work in anesthetized dogs.
Why the study?
Does eel ventricular natriuretic peptide have different renal and cardiovascular effects compared to ANP and BNP in anesthetized dogs?
Does eel ventricular natriuretic peptide have different renal and cardiovascular effects compared to ANP and BNP in anesthetized dogs?
Eel ventricular natriuretic peptide exhibits potent natriuretic effects similar to ANP and BNP but lacks the cardiac-suppressive effects seen with BNPs in anesthetized dogs.
May inform natriuretic peptide development without cardiac suppression in dogs; leaves open human translation.
Ventricular natriuretic peptide (VNP), a possibly new type of natriuretic peptide with an extended C-terminal tail, has been isolated from eel cardiac ventricles. We investigated the effects of eel VNP on the kidney and cardiovascular system and compared these results with those of mammalian peptides in dogs. Eel VNP, human (dog) ANP, human and dog BNPs were infused into the renal artery at non-hypotensive doses. All peptides produced similar diuresis and natriuresis, but cardiac output and the left and right ventricular stroke work were decreased by BNPs, but ANP and eel VNP did not change these parameters. Systemic vascular resistance was increased by BNPs, but unaffected by other peptides. These results show that eel VNP has renal effects similar to ANP and BNP, but it elicits responses in the heart different from those of BNPs in anesthetized dogs.
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Arai et al. (1996) studied Healthy (anesthetized animal model) (n=30). Eel ventricular natriuretic peptide (VNP) vs. Saline, human (dog) ANP, human BNP, and dog BNP was evaluated on Renal function (diuresis, natriuresis) and cardiovascular hemodynamics (cardiac output, stroke work, vascular resistance). Eel ventricular natriuretic peptide produced similar diuresis and natriuresis to ANP and BNP, but unlike BNP, it did not decrease cardiac output or stroke work in anesthetized dogs.
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