Key result
Eel VNP demonstrates greater natriuretic and vasodepressor potency than human ANP.
Why the study?
A novel natriuretic peptide with unique structural and functional properties was isolated from eel cardiac ventricles, differing from mammalian peptides.
Population
Eel cardiac ventricles and rat and eel models for activity testing
Comparison
Eel ventricular natriuretic peptide (VNP) vs human atrial natriuretic peptide (ANP)
Design
Preclinical isolation and activity study
Authors
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Eel VNP discovery reveals non-mammalian natriuretic peptide diversity; leaves open any human homolog or therapeutic relevance.
A novel natriuretic peptide (VNP) isolated from eel cardiac ventricles demonstrates potent natriuretic and vasodepressor activities in both eels and rats.
Takei et al. (1991) studied this question. Ventricular natriuretic peptide (VNP) vs. Human ANP was evaluated on Natriuretic and vasodepressor activities. Ventricular natriuretic peptide (VNP) isolated from eel cardiac ventricles demonstrated greater natriuretic and vasodepressor potency than human ANP in eels and similar potency in rats.
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