Key result
Seawater transfer reduces eel NPR-B mRNA levels, which share ~84% cytoplasmic similarity with mammalian receptors.
Population
Eel gill natriuretic-peptide receptor B cloned and expressed in COS-1 cells, and eel tissues
Comparison
Transfer of eels from fresh water to seawater… vs Eels kept in fresh water
Design
Preclinical
Follow-up
2 weeks
Authors
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Eel NPR-B conservation and seawater downregulation may inform osmoregulatory mechanisms; leaves open whether findings extend to mammalian natriuretic pathways.
The eel NPR-B receptor shares high cytoplasmic but low extracellular sequence similarity with mammalian counterparts, and its expression is downregulated during adaptation to seawater, suggesting a role in osmotic regulation.
Katafuchi et al. (1994) studied this question. Cloning and expression of eel natriuretic-peptide receptor B vs. Mammalian counterparts was evaluated on Sequence similarity and mRNA expression levels. The eel NPR-B receptor showed 44% extracellular and 84% cytoplasmic sequence similarity to mammalian receptors, with mRNA levels decreasing upon transfer to seawater.
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