Key result
Eel NPR-C shows a unique interchain disulfide linkage versus mammalian NPR-C and salinity-dependent expression.
Population
Eel gill cDNA library and euryhaline eel model
Comparison
Site-directed mutagenesis and transfer from… vs Mammalian NPR-C and fresh water conditions
Design
Preclinical
Authors
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No immediate clinical implications for human NPR-C; leaves open comparative receptor biology in non-mammalian models.
Eel NPR-C has a unique interchain disulfide linkage compared to mammalian NPR-C and its expression regulation suggests a role in adaptation to salinity changes.
Takashima et al. (1995) studied this question. Eel natriuretic peptide receptor C possesses a unique interchain disulfide linkage compared to mammalian NPR-C, and its expression is regulated by salinity changes in euryhaline eels.
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