Key result
The rate of Ca 45 transfer increases considerably during contraction in isolated guinea-pig atria, and the increment in calcium uptake is closely correlated with the strength of contraction.
Population
isolated guinea-pig atria
Comparison
contraction induced by stimulation at different… vs rest
Design
Preclinical
Authors
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Should not change practice; hypothesis-generating for calcium-dependent contractility in isolated myocardium.
This preclinical study demonstrates a direct correlation between calcium uptake and the strength of contraction in isolated heart muscle.
Brooks et al. (1961) studied this question. Contraction vs. Rest was evaluated on Transfer of Ca 45. The rate of Ca 45 transfer increases considerably during contraction in isolated guinea-pig atria, and the increment in calcium uptake is closely correlated with the strength of contraction.
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