Key result
Time of day was associated with the onset of nonfatal myocardial infarction and sudden cardiac death, exhibiting a primary peak in the morning and a secondary peak in the evening.
Why the study?
Is there a circadian variation in the onset of nonfatal myocardial infarction and sudden cardiac death?
Observational (n=2,906)
Is there a circadian variation in the onset of nonfatal myocardial infarction and sudden cardiac death?
Nonfatal myocardial infarction and sudden cardiac death exhibit a prominent circadian rhythm with a primary peak in the morning, potentially linked to increased morning platelet aggregability.
Should not yet change practice; leaves open whether timed interventions reduce morning MI/SCD events.
The events that convert chronic coronary artery disease to acute myocardial infarction or sudden cardiac death are poorly understood. We studied the time of day of onset of nonfatal myocardial infarction (as judged objectively by CK-MB values, n = 703) and sudden cardiac death (as judged by death certificates, n = 2,203) to determine if there was an increased incidence associated with a particular time of day. Both conditions were found to have prominent circadian rhythms with a primary peak in the morning and a secondary peak in the evening. Platelet aggregability, which has been proposed as a component of myocardial infarction and sudden cardiac death, was also found to increase during the morning. These findings suggest a mechanism for myocardial infarction and sudden cardiac death and may lead to improved methods of prevention.
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Muller et al. (1987) conducted an observational in Nonfatal myocardial infarction and sudden cardiac death (n=2,906). Time of day vs. Other times of day was evaluated on Incidence of nonfatal myocardial infarction and sudden cardiac death by time of day. Time of day was associated with the onset of nonfatal myocardial infarction and sudden cardiac death, exhibiting a primary peak in the morning and a secondary peak in the evening.
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