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Antipsychotic medications induce neuroleptic malignant syndrome in 0.02% to 0.03% of patients, causing rigidity, hyperthermia, and autonomic dysfunction with mortality up to 5.6%.
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Neuroleptic malignant syndrome is a rare but severe condition associated with antipsychotic use, characterized by autonomic dysfunction and high mortality.
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Tan et al. (2023) studied this question. Antipsychotic medications induce neuroleptic malignant syndrome in 0.02% to 0.03% of patients, causing rigidity, hyperthermia, and autonomic dysfunction with mortality up to 5.6%.
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