Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy

Figure 1.. Comparison of the impact of early or late developmental cardiac FKBP12 deficiency in the adult mouse heart. Comparison of control, MCK-FKBP, and αMHC-FKBP-deficient mice and the alterations in cardiac structure and function observed at a whole heart and cardiomyocyte level at 3 mo of age. Findings from Hanna et al. (2025) illustrate that FKBP12 expression is crucial at embryonic day E9 as cardiac structure and function are altered in the αMHC-FKBP-deficient mice. These notable cardiac changes are absent in MCK-FKBP-deficient mice lacking FKBP12 expression from embryonic day E13.5. Created with BioRender.