Key result
Verapamil reduced systolic and diastolic blood pressure by decreasing total peripheral vascular resistance in patients with uncomplicated essential hypertension.
Why the study?
Does verapamil reduce blood pressure and alter hemodynamics in patients with uncomplicated essential hypertension?
Does verapamil reduce blood pressure and alter hemodynamics in patients with uncomplicated essential hypertension?
Verapamil effectively lowers blood pressure in essential hypertension by reducing peripheral vascular resistance while maintaining renal perfusion and enhancing sodium excretion.
Hypothesis-generating for verapamil in uncomplicated hypertension; prospective trials needed before clinical adoption.
In fifteen patients with uncomplicated essential hypertension verapamil reduced systolic as well as diastolic blood pressure by virtue of a decrease in total peripheral vascular resistance. Renal vascular resistance also fell, but renal perfusion was well maintained. Although levels of renin and angiotensin II remained unchanged, aldosterone levels fell significantly. Noradrenaline levels rose slightly, but changes were not significant. On the other hand adrenaline was significantly reduced. Renal sodium excretion was markedly enhanced, perhaps secondary to aldosterone suppression. Despite sodium loss, plasma volume increased suggesting that verapamil not only lowers arterial but also venous resistance.
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Leeuw et al. (1984) studied uncomplicated essential hypertension (n=15). Verapamil was evaluated on systolic and diastolic blood pressure. Verapamil reduced systolic and diastolic blood pressure by decreasing total peripheral vascular resistance in patients with uncomplicated essential hypertension.
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