Key result
A mathematical model of mRNA turnover and experimental findings shed light on the molecular mechanisms of mRNA decay rates in shaping the kinetics of gene activation and repression.
This review highlights the importance of mRNA decay rates in shaping the kinetics of gene expression using mathematical modeling.
Does not alter cardiovascular practice; leaves open mRNA decay modeling for cardiac gene regulation studies.
Broader comprehension of gene expression regulatory mechanisms can be gained from a global analysis of how transcription and degradation are coordinated to orchestrate complex cell responses. The role of messenger RNA (mRNA) turnover modulation in gene expression levels has become increasingly recognized. From such perspective, in this review we briefly illustrate how a simple but effective mathematical model of mRNA turnover and some experimental findings, may together shed light on the molecular mechanisms underpinning the major role of mRNA decay rates in shaping the kinetics of gene activation and repression. WIREs RNA 2015, 6:327–336. doi: 10.1002/wrna.1277 This article is categorized under: RNA Turnover and Surveillance > Regulation of RNA Stability
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Palumbo et al. (2015) conducted a review in Gene expression and mRNA turnover. A mathematical model of mRNA turnover and experimental findings shed light on the molecular mechanisms of mRNA decay rates in shaping the kinetics of gene activation and repression.
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