Key result
Indomethacin treatment substantially reduced the pressure range of renal blood flow autoregulation in 40-week-old spontaneously hypertensive rats (154-146 mmHg vs 169-130 mmHg in untreated; P<0.001).
Why the study?
Does indomethacin treatment affect renal blood flow autoregulation in spontaneously hypertensive rats?
Population
10- and 40-week-old spontaneously hypertensive rats (SHR)
Comparison
Acute and chronic indomethacin treatment vs Untreated spontaneously hypertensive rats
Design
Preclinical
Authors
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Indomethacin impairs renal autoregulation in aged hypertensive rats; leaves open clinical relevance in humans.
Does indomethacin treatment affect renal blood flow autoregulation in spontaneously hypertensive rats?
p-value: p=<0.001
Cyclooxygenase inhibition with indomethacin impairs renal blood flow autoregulation in older spontaneously hypertensive rats, an effect that appears to be mediated by the renal nerves.
Iversen et al. (1992) studied Spontaneously hypertensive rats (SHR). Indomethacin treatment vs. Untreated SHR was evaluated on Pressure range of renal blood flow autoregulation (p=<0.001). Indomethacin treatment substantially reduced the pressure range of renal blood flow autoregulation in 40-week-old spontaneously hypertensive rats (154-146 mmHg vs 169-130 mmHg in untreated; P<0.001).
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