A method has been described in detail by which rats and guinea‐pigs were subjected to graded degrees of trauma. Following such a procedure mortality curves were obtained indicating that strictly quantitative results could be produced. Animals subjected to this type of trauma develop hæmoconcentration and the pathological changes ascribed to the condition of shock. The complications of hæmorrhage, infection and anæsthesia are not associated with the shock so produced. Some theories for the ætiology of shock are discussed, and from the experimental results obtained a modification of the toxic substance theory is suggested.
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Noble et al. (1942) studied this question.