Lower Risk of Multisystem Inflammatory Syndrome in Children With the Delta and Omicron Variants of Severe Acute Respiratory Syndrome Coronavirus 2

Jonathan Cohen; Michael J. Carter; Ronny Cheung; Shamez Ladhani

doi:10.1093/cid/ciac553

July 5, 2022Clinical Infectious DiseasesOpen Access

Lower Risk of Multisystem Inflammatory Syndrome in Children With the Delta and Omicron Variants of Severe Acute Respiratory Syndrome Coronavirus 2

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Key Points

To evaluate the risk of multisystem inflammatory syndrome in children (MIS-C) across different SARS-CoV-2 variant eras.
Evaluated incidence rates of MIS-C per confirmed SARS-CoV-2 infection in children aged 0–16 years in southeast England.
Compared risk across prevaccine Delta, postvaccine Delta, and Omicron variant circulation periods using rate ratios.
MIS-C rates per confirmed infection decreased during the prevaccine Delta period (reported as 56% lower; rate ratio [RR], 0.34; 95% CI, .23–.50).
Rates remained suppressed during the postvaccine Delta period (reported as 66% lower; RR, 0.44; 95% CI, .28–.69).
The Omicron period demonstrated the largest drop in MIS-C risk, showing a 95% reduction per confirmed infection (RR, 0.05; 95% CI, .02–.10).

Implication

Reveals significantly reduced rates of multisystem inflammatory syndrome in pediatric coronavirus infections during Delta and Omicron waves, indicating attenuated post-infectious inflammatory risk.

Abstract

Little is known about the risk of multisystem inflammatory syndrome in children (MIS-C) with different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. In southeast England, MIS-C rates per confirmed SARS-CoV-2 infections in children aged 0-16 years were 56% lower (rate ratio [RR], 0.34 [95% confidence interval {CI}, .23-.50]) during prevaccine Delta, 66% lower (RR, 0.44 [95% CI, .28-.69]) during postvaccine Delta, and 95% lower (RR, 0.05 [95% CI, .02-.10]) during the Omicron period.

Discussion

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Cite This Study

Cohen et al. (2022) studied this question.

synapsesocial.com/papers/6a9cdf3bf8b9018827736b65 https://doi.org/10.1093/cid/ciac553

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Lower Risk of Multisystem Inflammatory Syndrome in Children With the Delta and Omicron Variants of Severe Acute Respiratory Syndrome Coronavirus 2

Key Points

Implication

Abstract

Discussion

Cite This Study

Lower Risk of Multisystem Inflammatory Syndrome in Children With the Delta and Omicron Variants of Severe Acute Respiratory Syndrome Coronavirus 2

Key Points

Implication

Abstract

Discussion

Cite This Study

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