Pharmacokinetics of FK506 and mycophenolic acid in experimental and clinical intestinal transplantation

Rejection control remains the crucial problem of intestinal transplantation. Currently, this type of transplantation requires prolonged administration of high-dose immunosuppressive treatment via parenteral route, resulting in a high incidence of toxicity.1−3 The aim of our study is to investigate the pharmacokinetics of both FK506 and mycophenolic acid (MPA) after oral administration in swine and human intestinal transplantation and to verify whether administration via oral route only is sufficient to reach and subsequently to maintain target drug levels.