Key result
Maternal exposure to teratogens during the first trimester of pregnancy was associated with a significantly increased odds of congenital heart disease in offspring (OR 2.32).
Why the study?
Improving knowledge of risk factors for congenital heart disease is important due to its high mortality and morbidity and to aid prevention efforts.
What are the maternal and environmental risk factors associated with congenital heart disease in children?
Population
898 children with their mothers in Isfahan, Iran
Comparison
464 children with echocardiography-confirmed CHD vs 434 sex- and age-matched controls without CHD
Design
Hospital-based case-control study
Authors
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May inform preconception counseling; leaves open causal validation in prospective cohorts.
Case-Control (n=910)
No
What are the maternal and environmental risk factors associated with congenital heart disease in children?
Odds Ratio: 2.32 (95% CI 1.68–3.2)
p-value: p=< 0.001
Maternal obesity, abortion history, parental consanguinity, and exposure to teratogens, medications, or cigarette smoke during pregnancy are significant risk factors for congenital heart disease.
Ahmadi et al. (2020) conducted a case-control in Congenital heart disease (n=910). Maternal exposure to teratogens vs. Unexposed mothers was evaluated on Odds of congenital heart disease (OR 2.32, 95% CI 1.68-3.20, p=< 0.001). Maternal exposure to teratogens during the first trimester of pregnancy was associated with a significantly increased odds of congenital heart disease in offspring (OR 2.32).
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