Key result
Acetone concentrations of 0.5% and 1.0% V/V significantly reduced the force of contraction and significantly increased heart rate and coronary flow in isolated rabbit hearts.
Why the study?
Does acetone perfusion affect heart rate, force of contraction, and coronary flow in isolated rabbit hearts?
Does acetone perfusion affect heart rate, force of contraction, and coronary flow in isolated rabbit hearts?
Acetone at 0.5% and 1.0% V/V concentrations significantly reduces force of contraction and increases heart rate and coronary flow in isolated rabbit hearts.
Answers are grounded in this paper and cite their sources.
No immediate clinical implications; leaves open translation of acetone effects from isolated rabbit hearts to humans.
In-vitro toxicity of acetone using isolated rabbit heart is reported. The hearts were perfused using Langendorf's procedure and modified Anderson's coronary perfusion apparatus. Heart rate and force of contraction were recorded mechanically and the coronary flow was measured manually. The force of contraction was significantly reduced; heart rate and coronary flow were significantly increased with acetone concentrations of 0.5% and 1.0% V/V.
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Ravindra R. Raje (1980) studied this question. Acetone was evaluated on Heart rate, force of contraction, and coronary flow. Acetone concentrations of 0.5% and 1.0% V/V significantly reduced the force of contraction and significantly increased heart rate and coronary flow in isolated rabbit hearts.
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