What is the clinical evidence from this study?

Study design: Other. Intervention: ONO3708. Primary outcome: Vascular contraction and relaxation.

What question did this study set out to answer?

To examine the pharmacological interactions of the thromboxane A2 analog ONO3708 with contractile and relaxant prostaglandins in isolated canine arteries.

January 1, 1987Journal of Cardiovascular Pharmacology

Interactions of Thromboxane A2 Analogs and Prostaglandins in Isolated Dog Arteries

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Key result

ONO3708 selectively antagonized the vasoconstrictor action of TXA2 analogs and prostaglandins in isolated dog arteries without altering the action of vasodilator prostaglandins.

Why the study?

Does ONO3708 antagonize the vasoconstrictor action of TXA2 analogs and prostaglandins in isolated dog arteries?

Population

Helical strips of dog cerebral, coronary, renal, and mesenteric arteries

Comparison

ONO3708 at concentrations up to 10 M vs Baseline response to sTXA2 and prostaglandins…

Design

Preclinical

Authors

NTNoboru TodaToyama College MNMasatoshi NakajimaTokyo University of Pharmacy and Life Sciences TOTomio OkamuraShiga University of Medical Science

Discussion

Member takes

Implication

Hypothesis-generating for selective TXA2 antagonism in vascular disease; human studies required before clinical consideration.

Key Points

To examine the pharmacological interactions of the thromboxane A2 analog ONO3708 with contractile and relaxant prostaglandins in isolated canine arteries.
Tested vascular tension in helical strips from dog cerebral, coronary, renal, and mesenteric arteries.
Measured arterial responses to epithio-methano-TXA2, prostaglandins (PGF2alpha, PGE2, PGD2, PGI2, PGH2), and norepinephrine across various concentrations of ONO3708.
ONO3708 (up to 10^-6 M) lacked intrinsic contractile activity but dose-dependently suppressed contractions induced by sTXA2, with greater inhibition observed in renal arteries.
Treatment with ONO3708 (3 x 10^-9 and 10^-8 M) similarly suppressed contractions caused by PGF2alpha, PGE2, and PGD2, abolished PGH2-induced contractions at 10^-7 M, and potentiated PGH2-mediated relaxation.
ONO3708 did not alter norepinephrine-induced contractions (up to 2 x 10^-7 M) or PGI2-induced relaxant responses in cerebral and renal arteries.

Structured PICO

Does ONO3708 antagonize the vasoconstrictor action of TXA2 analogs and prostaglandins in isolated dog arteries?

Population

Helical strips of dog cerebral, coronary, renal, and mesenteric arteries

Intervention

ONO3708 (thromboxane A2 analog) at concentrations up to 10(-6) M

Comparator

Baseline response to sTXA2 and prostaglandins without ONO3708

Outcome

Vascular contraction and relaxation responsessurrogate

ONO3708 selectively antagonizes the vasoconstrictor action of TXA2 and prostaglandins without altering vasodilator prostaglandins in isolated dog arteries.

Cite This Study

Toda et al. (1987) studied this question. ONO3708 was evaluated on Vascular contraction and relaxation. ONO3708 selectively antagonized the vasoconstrictor action of TXA2 analogs and prostaglandins in isolated dog arteries without altering the action of vasodilator prostaglandins.

synapsesocial.com/papers/6a9cec9ea2aa65bfe097b241 https://doi.org/10.1097/00005344-198709010-00025

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Interactions of Thromboxane A2 Analogs and Prostaglandins in Isolated Dog Arteries

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Interactions of Thromboxane A2 Analogs and Prostaglandins in Isolated Dog Arteries

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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