Key result
In vitro myotube formation from embryonic avian muscle myoblasts requires insulin, a low-molecular-weight fusion factor, and a collagen substratum, without which only globular structures form.
Why the study?
Does a collagen substratum promote myotube formation in embryonic avian muscle myoblasts in vitro?
Does a collagen substratum promote myotube formation in embryonic avian muscle myoblasts in vitro?
Collagen is essential for the proper formation of myotubes from embryonic avian muscle myoblasts in vitro, preventing the formation of abnormal globular syncytial structures.
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Collagen substratum prevents abnormal globular structures in avian myoblast cultures; leaves open whether matrix requirements apply to mammalian myogenesis models.
Haba et al. (1975) studied Embryonic avian muscle myoblasts (in vitro). Collagen substratum, insulin, and low-molecular-weight fusion factor vs. Absence of collagen was evaluated on Myotube formation. In vitro myotube formation from embryonic avian muscle myoblasts requires insulin, a low-molecular-weight fusion factor, and a collagen substratum, without which only globular structures form.
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