Key result
Intravascular hemolysis decreases the pressor response to angiotonin, supporting the hypothesis that physiological angiotonin destruction occurs entirely in the plasma.
Population
Animal model (implied by references to 'the normal animal', 'nephrectomy', and 'evisceration')
Comparison
Physiological manipulations and angiotonin… vs Baseline or normal physiological state
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open human translation of plasma angiotensin degradation.
This early preclinical study provides evidence that angiotonin (angiotensin) destruction under physiological circumstances occurs primarily in the plasma.
Sapirstein et al. (1946) studied Angiotonin destruction. Physiological and in vitro manipulations (e.g., nephrectomy, hemorrhage, hemolysis) was evaluated on Magnitude and duration of the pressor response to angiotonin. Intravascular hemolysis decreases the pressor response to angiotonin, supporting the hypothesis that physiological angiotonin destruction occurs entirely in the plasma.
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