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Several angularly functionalized decalins, synthethized during the preparation of three keto diacetate decalins, models for clerodane diterpenoids, were tested for antifeedant activity against the spruce budworm, Choristoneura fumiferana. Definite biological activity was observed for some of these compounds. A structure–activity relationship was discussed on the basis of these results.
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Schwerdtfeger et al. (1993) studied this question.
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