Key result
Two LC/MS/MS assays were developed and validated to quantify the active and inactive metabolites of prasugrel in human plasma, demonstrating accuracy and precision within +/-20% at the lower limit.
Population
Human plasma
Design
Other
Authors
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Enables prasugrel metabolite quantification in research settings; leaves open clinical adoption pending patient cohort validation.
The developed LC/MS/MS assays provide a fast, sensitive, and validated method for quantifying prasugrel metabolites in human plasma, highlighting the necessity of immediate derivatization for active metabolite stability.
Farid et al. (2006) studied this question. LC/MS/MS-based bioanalytical assays for prasugrel metabolites was evaluated on Assay accuracy and precision for active and inactive metabolites of prasugrel. Two LC/MS/MS assays were developed and validated to quantify the active and inactive metabolites of prasugrel in human plasma, demonstrating accuracy and precision within +/-20% at the lower limit.
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