Key result
Doppler echocardiography-derived systolic pulmonary artery pressure ≥41 mmHg and tricuspid regurgitation pressure gradient ≥36 mmHg accurately detected pulmonary hypertension with an AUC of 0.95.
Why the study?
The cutoff value of Doppler-derived sPAP or TRPG for detecting an invasively determined mean PAP >= 25 mmHg has not been well defined.
Cross-Sectional (n=189)
No
Effect estimate: AUC 0.95
These thresholds should not yet change practice; leaves open prospective validation against catheterization.
Pulmonary hypertension (PH) is defined as a mean pulmonary artery pressure (PAP) ≥ 25 mmHg at rest as assessed by right heart catheterization (RHC), and Doppler-derived systolic PAP (sPAPECHO) or tricuspid regurgitation pressure gradient (TRPG) is widely used to screen for PH. However, the cutoff value of sPAPECHO or TRPG for detecting a mean PAP ≥ 25 mmHg that was determined invasively has not been well defined.
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Sawada et al. (2019) conducted a cross-sectional in Pulmonary hypertension (n=189). Doppler echocardiography (sPAPECHO and TRPG) vs. Right heart catheterization was evaluated on Detection of pulmonary hypertension (mean PAP ≥ 25 mmHg) by sPAPECHO (AUC 0.95). Doppler echocardiography-derived systolic pulmonary artery pressure ≥41 mmHg and tricuspid regurgitation pressure gradient ≥36 mmHg accurately detected pulmonary hypertension with an AUC of 0.95.
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