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Acutumine was first isolated from Sinomenium acutum Rehd. et Wills. (Menispermaceae) by K. Goto and H. Sudzuki,l' who proposed an empirical formula either C20H27N08 or C21H27N08 and the presence of a ketone, an N-methyl and a carboxyl group and three methoxyl groups.
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Goto et al. (1966) studied this question.
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