Key result
High concentrations of propofol (100 microM) suppressed type 1 cyclooxygenase activity and enhanced STA2-induced inositol 1,4,5-triphosphate formation in human platelets in vitro.
Why the study?
Does propofol alter human platelet aggregation in vitro?
Population
Human platelets in vitro
Comparison
Propofol added 5 min before induction of reaction vs Equivalent volume of 10% Intralipos
Design
Preclinical
Authors
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Should not alter propofol use; leaves open clinical relevance of in vitro platelet effects.
Does propofol alter human platelet aggregation in vitro?
Propofol exhibits concentration-dependent dual effects on human platelet aggregation in vitro by suppressing type 1 cyclooxygenase activity at high concentrations while enhancing STA2-induced inositol 1,4,5-triphosphate formation.
Hirakata et al. (1999) studied this question. Propofol vs. 10% Intralipos was evaluated on Platelet aggregation and TXA2 formation. High concentrations of propofol (100 microM) suppressed type 1 cyclooxygenase activity and enhanced STA2-induced inositol 1,4,5-triphosphate formation in human platelets in vitro.
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