Key result
Propofol at clinical concentrations (2-10 μg/mL) had no significant inhibitory effect on platelet aggregation in blood from healthy volunteers after up to 3 hours of incubation.
Why the study?
Does propofol at clinical concentrations affect platelet aggregation in vitro?
Population
Blood from healthy volunteers (n = 9)
Comparison
Propofol at plasma concentrations of 2, 4, and… vs Propofol plasma concentration of 0 μg/mL (control)
Design
Preclinical
Follow-up
3 hours (incubation time)
Authors
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May support propofol safety on platelet function in vitro; hypothesis-generating and requires in vivo confirmation before practice implications.
Does propofol at clinical concentrations affect platelet aggregation in vitro?
Propofol at concentrations required for sedation and general anesthesia does not inhibit platelet aggregation in vitro up to 3 hours.
Chung et al. (2012) studied Healthy volunteers (n=9). Propofol vs. 0 μg/mL was evaluated on Platelet aggregation (closure times to occlude CEPI or CADP-coated membranes). Propofol at clinical concentrations (2-10 μg/mL) had no significant inhibitory effect on platelet aggregation in blood from healthy volunteers after up to 3 hours of incubation.
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