Key result
Thiopental-fentanyl-sevoflurane significantly reduced collagen-induced platelet aggregation by the end of induction, whereas propofol-fentanyl-sevoflurane had no effect on platelets.
Why the study?
Does thiopental-based anaesthesia compared to propofol-based anaesthesia affect platelet function in patients undergoing thyroid surgery?
Population
20 patients undergoing thyroid surgery and in vitro experiments
Comparison
Thiopental-fentanyl-sevoflurane anaesthesia vs Propofol-fentanyl-sevoflurane anaesthesia
Design
Cohort
Follow-up
End of surgery
Authors
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Thiopental may impair platelet function during induction; leaves open whether propofol is hemostatically preferable and requires randomized confirmation.
Observational (n=20)
Does thiopental-based anaesthesia compared to propofol-based anaesthesia affect platelet function in patients undergoing thyroid surgery?
Thiopental, but not propofol, reduces platelet function during anaesthesia induction, suggesting propofol may be a haemostatically safer choice.
Dordoni et al. (2004) conducted an observational in Thyroid surgery (n=20). Thiopental-fentanyl-sevoflurane vs. Propofol-fentanyl-sevoflurane was evaluated on Platelet aggregation and thromboxane A2 generation. Thiopental-fentanyl-sevoflurane significantly reduced collagen-induced platelet aggregation by the end of induction, whereas propofol-fentanyl-sevoflurane had no effect on platelets.
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