November 1, 1998European Journal of Anaesthesiology

Volatile anaesthetics induce changes in the expression of P-selectin and glycoprotein Ib on the surface of platelets in vitro

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Population

Platelets in vitro

Design

Preclinical

Authors

DFDieter FröhlichRegensburg University of Applied Sciences GRG. RotheLeiden University GSGerd SchmitzSemmelweis University

Discussion

Member takes

Implication

These in vitro platelet effects are hypothesis-generating; should not yet alter anesthetic selection or perioperative practice.

Structured PICO

Population

Platelets in vitro

Intervention

In vitro exposure to volatile anaesthetics (sevoflurane, halothane, isoflurane, desflurane, N2O)

Outcome

Expression of the adhesion molecule P-selectin and internalization of the receptor for von Willebrand factor (GPlb)surrogate

Several volatile anaesthetics induce in vitro changes in P-selectin and GPlb expression characteristic of platelet activation, without interfering with ADP stimulation.

Cite This Study

Fröhlich et al. (1998) studied this question.

synapsesocial.com/papers/6a82ff21f71f34e1aae8de80 https://doi.org/10.1097/00003643-199811000-00004

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Volatile anaesthetics induce changes in the expression of P-selectin and glycoprotein Ib on the surface of platelets in vitro

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Volatile anaesthetics induce changes in the expression of P-selectin and glycoprotein Ib on the surface of platelets in vitro

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider