Key result
Halothane, sevoflurane, and propofol reversibly inhibit platelet function at clinical concentrations, while other common anaesthetics and opioids have negligible effects.
Why the study?
Do anaesthetic drugs affect platelet function and membrane receptors?
Population
Surgical patients and platelets (in vitro and in vivo studies)
Design
Review
Authors
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Potential perioperative bleeding risk warrants anaesthetic caution; leaves open prospective outcome trials.
Do anaesthetic drugs affect platelet function and membrane receptors?
Certain anaesthetics like halothane, sevoflurane, and propofol inhibit platelet function at clinical concentrations, which may aggravate the risk of perioperative bleeding.
Sibylle A. Kozek‐Langenecker (2002) conducted a review in Perioperative bleeding disorders and platelet dysfunctions. Anaesthetic drugs (inhalational, intravenous, local, opioids, muscle relaxants) was evaluated on Platelet function and membrane receptors. Halothane, sevoflurane, and propofol reversibly inhibit platelet function at clinical concentrations, while other common anaesthetics and opioids have negligible effects.
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