Key result
Thiopental inhibited prostaglandin-induced platelet activation at therapeutic concentrations both in vitro and ex vivo in cardiac surgical patients.
Why the study?
Do anesthetic drugs commonly used in cardiac surgery affect platelet function?
Population
Anticoagulated whole blood (in vitro) and 10 patients undergoing elective coronary surgery (ex vivo)
Comparison
Anesthetic drugs commonly used in cardiac surgery vs Basal conditions
Design
Cohort
Follow-up
48 hours after surgery
Authors
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Thiopental may impair platelet function in cardiac surgery; hypothesis-generating for bleeding outcomes and requires prospective confirmation.
Observational (n=10)
Do anesthetic drugs commonly used in cardiac surgery affect platelet function?
Thiopental administration may contribute to the in vivo impairment of platelet function in patients undergoing elective cardiac surgery by inhibiting prostaglandin-induced platelet activation.
Parolari et al. (1999) conducted an observational in Elective coronary surgery (n=10). Thiopental and other common cardiac anesthetics vs. Basal conditions (pre-administration) was evaluated on Platelet response to U46619 (P-selectin expression and aggregation). Thiopental inhibited prostaglandin-induced platelet activation at therapeutic concentrations both in vitro and ex vivo in cardiac surgical patients.
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