Key result
Intravenous prenalterol increased systolic blood pressure by 26% (P<0.002) and left ventricular ejection fraction, but isoprenaline produced a greater increase in ejection fraction and cardiac output.
Why the study?
Does intravenous prenalterol improve ventricular performance compared to isoprenaline in patients with ischaemic heart disease?
Population
9 patients with ischaemic heart disease with varying degrees of impairment of ventricular performance
Comparison
Intravenous prenalterol (1 mg and 2 mg) vs Intravenous isoprenaline infused at 1…
Design
Case_series
Authors
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Prenalterol may improve LVEF less than isoprenaline; case report leaves open any clinical role in ischaemic heart disease.
Does intravenous prenalterol improve ventricular performance compared to isoprenaline in patients with ischaemic heart disease?
Intravenous prenalterol increases systolic blood pressure and LVEF in ischaemic heart disease, but its effects on ventricular performance are less pronounced than isoprenaline and may be limited by increased cardiac afterload.
Muir et al. (1981) studied Ischaemic heart disease (n=9). Intravenous prenalterol vs. Isoprenaline (1 microgram/min) was evaluated on Ventricular performance assessed by radionuclide ventriculography. Intravenous prenalterol increased systolic blood pressure by 26% (P<0.002) and left ventricular ejection fraction, but isoprenaline produced a greater increase in ejection fraction and cardiac output.
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