Key result
Acute administration of prenalterol in patients with CAD increased rate pressure product by 40% (P<0.01) and myocardial oxygen consumption by 20% (P<0.05) at rest, indicating increased oxygen demand.
Why the study?
Does acute administration of prenalterol alter coronary haemodynamics and myocardial metabolism in patients with coronary artery disease without evident congestive heart failure?
Does acute administration of prenalterol alter coronary haemodynamics and myocardial metabolism in patients with coronary artery disease without evident congestive heart failure?
Effect estimate: 40% increase
p-value: p=<0.01
Acute administration of the inotrope prenalterol increases myocardial oxygen demand and can induce myocardial ischemia in patients with coronary artery disease, suggesting it should be used cautiously in this population.
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Caution with prenalterol in CAD warranted; case-report data leaves open need for controlled ischemia trials.
Westheim et al. (1988) studied Coronary artery disease (CAD) without evident congestive heart failure (n=9). Prenalterol vs. Baseline (before prenalterol administration) was evaluated on Rate pressure product (RPP) at rest (40% increase, p=<0.01). Acute administration of prenalterol in patients with CAD increased rate pressure product by 40% (P<0.01) and myocardial oxygen consumption by 20% (P<0.05) at rest, indicating increased oxygen demand.
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