Key result
In isolated guinea pig cardiac myocytes, cytoplasmic Ca2+ movements propagate into the nucleus with a delay, suggesting the nuclear envelope restricts passive diffusion of cytoplasmic Ca2+.
Population
Isolated ventricular myocytes from guinea pigs of either sex, weighing 300 to 400 g.
Comparison
Electrical stimulation at 0.5 Hz, application of… vs Baseline conditions.
Design
Preclinical
Authors
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Does not support clinical changes; hypothesis-generating for nuclear Ca2+ regulation in cardiomyocytes.
Cytoplasmic Ca2+ movements in isolated guinea pig cardiomyocytes propagate into the nucleus with a delay, suggesting the nuclear envelope restricts passive diffusion.
Tanaka et al. (1996) studied Isolated guinea pig ventricular myocytes. Isoproterenol and low [Na+] conditions vs. Control conditions was evaluated on Nuclear and cytoplasmic Ca2+ concentration ([Ca2+]) upon stimulation. In isolated guinea pig cardiac myocytes, cytoplasmic Ca2+ movements propagate into the nucleus with a delay, suggesting the nuclear envelope restricts passive diffusion of cytoplasmic Ca2+.
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