Population
Quiescent cardiac myocytes isolated from guinea pig ventricle, loaded with fura-2
Design
Preclinical
Authors
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Provides mechanistic insight into myocyte Ca2+ heterogeneity in animal models; leaves open translation to human arrhythmia mechanisms.
Mitochondrial Ca2+ compartmentation is largely responsible for the spatial heterogeneity of intracellular Ca2+ concentration in quiescent guinea pig ventricular myocytes.
Williford et al. (1990) studied this question.
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