Key result
Dietary treatment of atherosclerosis with a regression diet for 18 months abolished the augmented cerebral vasoconstrictor responses to serotonin in cynomolgus monkeys.
Why the study?
Does dietary treatment of atherosclerosis reverse the augmented cerebral vasoconstrictor response to serotonin in cynomolgus monkeys?
Population
Cynomolgus monkeys (normal, atherosclerotic, and atherosclerotic fed a regression diet)
Comparison
Normal (regression) diet for 18 months vs Atherosclerotic monkeys and normal monkeys
Design
Preclinical
Follow-up
18 months
Authors
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Reverses cerebral vasomotor dysfunction in primate atherosclerosis; hypothesis-generating for dietary effects on human cerebrovascular risk.
Does dietary treatment of atherosclerosis reverse the augmented cerebral vasoconstrictor response to serotonin in cynomolgus monkeys?
Dietary regression of atherosclerosis in a primate model abolishes the augmented cerebral vasoconstrictor response to serotonin, suggesting a potential mechanism for reducing transient ischemic attacks.
Heistad et al. (1987) studied Atherosclerosis. Normal (regression) diet vs. Atherosclerotic monkeys and normal monkeys was evaluated on Cerebral vasoconstrictor response to serotonin (resistance of large cerebral arteries). Dietary treatment of atherosclerosis with a regression diet for 18 months abolished the augmented cerebral vasoconstrictor responses to serotonin in cynomolgus monkeys.
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