Key result
Atherosclerosis produced a 2-fold greater reduction in cerebral microvascular pressure in response to serotonin compared to normal monkeys, indicating potentiated constrictor responses.
Why the study?
Does atherosclerosis augment cerebral vasoconstrictor responses to serotonin in cynomolgus monkeys?
Population
16 cynomolgus monkeys (8 normal and 8 atherosclerotic fed an atherogenic diet for 17 months)
Comparison
Intracarotid infusion of serotonin, histamine… vs Normal cynomolgus monkeys
Design
Preclinical
Follow-up
17 months (diet duration)
Authors
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Indicates potential mechanism for cerebrovascular dysfunction; leaves open clinical relevance to human stroke risk.
Does atherosclerosis augment cerebral vasoconstrictor responses to serotonin in cynomolgus monkeys?
Effect estimate: 2-fold greater reduction
Atherosclerosis potentiates constrictor responses to serotonin in large cerebral arteries, suggesting a mechanism for altered cerebral vascular responses during platelet aggregation.
Tamaki et al. (1986) studied Atherosclerosis (n=16). Atherosclerosis (atherogenic diet) vs. Normal diet (normal monkeys) was evaluated on Cerebral microvascular pressure reduction in response to serotonin (2-fold greater reduction). Atherosclerosis produced a 2-fold greater reduction in cerebral microvascular pressure in response to serotonin compared to normal monkeys, indicating potentiated constrictor responses.
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