Key result
In patients with type 2 diabetes, diabetic retinopathy was associated with lower left hippocampal NAA levels compared to patients without retinopathy and correlated with cognitive impairment.
Why the study?
The study was conducted to explore the correlation between diabetic cognitive impairment and diabetic retinopathy by examining cognitive function and cerebral metabolism in T2DM using 1H-MRS.
Is diabetic cognitive impairment correlated with diabetic retinopathy and cerebral metabolism changes in patients with T2DM?
Observational (n=83)
No
Is diabetic cognitive impairment correlated with diabetic retinopathy and cerebral metabolism changes in patients with T2DM?
Diabetic retinopathy is associated with cognitive impairment and hippocampal metabolic changes in patients with type 2 diabetes.
Answers are grounded in this paper and cite their sources.
Retinopathy may flag hippocampal neuronal changes in diabetes but should not alter care; hypothesis-generating pending prospective validation.
Objective: To explore the correlation between diabetic cognitive impairment(DCI) and diabetic retinopathy (DR) through examining the cognitive function and the metabolism of the cerebrum in T2DM by 1H-MRS. Methods: 53 patients with T2DM were enrolled for this study. According to the fundus examination, the patients were divided into DR group (n=26) and T2DM without DR group (T2DM group, n=27). 30 healthy adults were selected as a control group (HC group, n=30). The cognitive function was measured by Montreal Cognitive Assessment (MoCA). The peak areas of N-acetylaspartate (NAA), Cho-line (Cho), Creatine (Cr) and Myo-inositol (mI), and their ratios were detected by proton magnetic resonance spectroscopy (1H-MRS). The difference analysis between the three groups was performed by one-way ANOVA. When p0.05). Conclusion: DCI is closely correlated with the DR in patients with T2DM. The hippocampal brain metabolism may have some changes in two sides of NAA in patients with DR, 1H-MRS may provide effective imaging strategies and methods to early diagnosis brain damage and quantitative assessment cognitive function in T2DM.
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Lu et al. (2019) conducted an observational in Type 2 diabetes mellitus with and without diabetic retinopathy (n=83). Diabetic retinopathy vs. Type 2 diabetes without retinopathy and healthy controls was evaluated on Left hippocampal N-acetylaspartate (NAA) levels (MD -8.12, 95% CI -15.25 to -1.00, p=0.026). In patients with type 2 diabetes, diabetic retinopathy was associated with lower left hippocampal NAA levels compared to patients without retinopathy and correlated with cognitive impairment.
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