Key result
Low-dose clozapine resolved psychotic features in all 20 Parkinson's disease patients, but caused increased generalized or focal EEG slowing in 25% of patients compared to pretreatment.
Why the study?
Does low-dose clozapine cause EEG changes in patients with Parkinson's disease and psychosis?
Observational (n=20)
Does low-dose clozapine cause EEG changes in patients with Parkinson's disease and psychosis?
Low-dose clozapine effectively resolves psychotic features in Parkinson's disease but can cause EEG changes such as generalized or focal slowing in a subset of patients.
Answers are grounded in this paper and cite their sources.
Alerts to possible EEG slowing with low-dose clozapine in PD psychosis; leaves open clinical consequences and need for controlled studies.
Twenty patients with Parkinson's disease (PD), who developed delusions and psychotic behavior, underwent electroencephalogram (EEG) recordings before and during treatment with low-dose clozapine. Resolution of the psychotic features was observed in all cases. The EEG was unaltered in 15, whereas five patients exhibited increased generalized or focal slowing when compared with the pretreatment tracings. These findings contrast with the high incidence of EEG abnormalities, including epileptiform activity, which are observed when larger doses of clozapine are used in schizophrenic patients, but they underscore that even in low doses, clozapine may cause EEG changes.
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Neufeld et al. (1996) conducted an observational in Parkinson's disease with delusions and psychotic behavior (n=20). Low-dose clozapine vs. Pretreatment baseline was evaluated on Increased generalized or focal EEG slowing. Low-dose clozapine resolved psychotic features in all 20 Parkinson's disease patients, but caused increased generalized or focal EEG slowing in 25% of patients compared to pretreatment.
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