Key result
Three days of treatment with Sheng-Mai-San reduced myocardial infarct size in rabbits through activation of protein kinase C and opening of mitochondrial KATP channels.
Why the study?
Does Sheng-mei-san reduce myocardial infarct size in Japanese white rabbits without collateral circulation?
Does Sheng-mei-san reduce myocardial infarct size in Japanese white rabbits without collateral circulation?
Preclinical evidence suggests that a 3-day treatment with the traditional Chinese formulation Sheng-mei-san reduces myocardial infarct size via PKC activation and mitochondrial KATP channel opening.
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Does not support clinical use of Sheng-Mai-San; leaves open translation of rabbit infarct-size reduction to humans.
Wang et al. (2001) studied Myocardial infarction. Sheng-Mai-San (SMS) was evaluated on Myocardial infarct size. Three days of treatment with Sheng-Mai-San reduced myocardial infarct size in rabbits through activation of protein kinase C and opening of mitochondrial KATP channels.
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