Why the study?
Does Shengmai San alleviate diabetes-induced myocardial hypertrophy and diastolic dysfunction in a diabetic mouse model?
Population
Leptin receptor-deficient db/db mice and palmitic acid-stimulated H9C2 cardiomyocytes. Lean age-matched…
Comparison
Shengmai San (SMS) at a dose of 3 g/kg body weight vs Untreated db/db mice and lean age-matched…
Design
Preclinical
Authors
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SMS may improve mitochondrial lipid metabolism in diabetic cardiomyopathy; leaves open translation to human therapy.
Does Shengmai San alleviate diabetes-induced myocardial hypertrophy and diastolic dysfunction in a diabetic mouse model?
Shengmai San alleviates diabetes-induced myocardial hypertrophy and diastolic dysfunction in a mouse model by improving mitochondrial lipid metabolism via the SIRT1/AMPK/PGC-1α pathway.
Tian et al. (2018) studied this question.
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