September 20, 2019Frontiers in PharmacologyOpen Access

Shengmai Injection Suppresses Angiotensin II-Induced Cardiomyocyte Hypertrophy and Apoptosis via Activation of the AMPK Signaling Pathway Through Energy-Dependent Mechanisms

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Why the study?

This study aimed to clarify the effects of Shengmai Injection on energy metabolism in cardiomyocyte hypertrophy and apoptosis.

Does Shengmai Injection suppress Angiotensin II-induced cardiomyocyte hypertrophy and apoptosis?

Structured PICO

Does Shengmai Injection suppress Angiotensin II-induced cardiomyocyte hypertrophy and apoptosis?

Population

Angiotensin II-induced hypertrophic cardiomyocytes

Intervention

Shengmai Injection (SMI)

Comparator

Angiotensin II alone, AMPK inhibitor (compound C), and AMPK knockdown (shAMPK)

Outcome

Cardiomyocyte hypertrophy and apoptosissurrogate

Shengmai Injection protects against Angiotensin II-induced cardiomyocyte hypertrophy and apoptosis by activating the AMPK signaling pathway and improving energy metabolism.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

SMI may protect mitochondria in HF cell models; leaves open clinical translation.

Cite This Study

Li et al. (2019) studied this question.

synapsesocial.com/papers/6a714bc375498292b70ac764 https://doi.org/10.3389/fphar.2019.01095

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Shengmai Injection Suppresses Angiotensin II-Induced Cardiomyocyte Hypertrophy and Apoptosis via Activation of the AMPK Signaling Pathway Through Energy-Dependent Mechanisms

Structured PICO

Discussion

Implication

Cite This Study

Shengmai Injection Suppresses Angiotensin II-Induced Cardiomyocyte Hypertrophy and Apoptosis via Activation of the AMPK Signaling Pathway Through Energy-Dependent Mechanisms

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider