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September 6, 2026Circulation Reports0 citationsOpen Access

Design and Rationale of the Niigata Cardiovascular Disease Registry Using Linked Administrative and Clinical Data (NiCARDIA)

SFShinya FujikiHIHayao IkesugiAHAkari Hagiwara

Key Result

The NiCARDIA registry is a prospective observational cohort designed to evaluate long-term functional trajectories in 8,500 adults hospitalized with cardiovascular disease.

Key Points

  • To describe the design and rationale of the NiCARDIA registry for investigating long-term functional decline in patients receiving contemporary cardiovascular disease care.
  • Integrated hospital-based clinical records with administrative health insurance claims datasets across Niigata Prefecture.
  • Established a prefecture-wide data-sharing platform to track longitudinal trajectories of functional independence and clinical outcomes.
  • Created a unified data-linkage infrastructure bridging acute hospital records and administrative claims data.
  • Established a population-based framework to systematically characterize real-world functional trajectories following cardiovascular interventions.

Study Design

Type

Observational (n=8,500)

Multicenter

Yes

Structured PICO

P
Population
A planned prospective observational cohort of 8,500 adults hospitalized with cardiovascular disease in Niigata Prefecture, Japan, followed for up to 20 years.
O
Outcome
Longitudinal change in functional independence assessed by transitions in certified long-term care-need levels (transitions between nine functional states: independent, support levels 1-2, care levels 1-5, and death)

The NiCARDIA registry will link hospital-based clinical data with population-level administrative datasets to comprehensively evaluate long-term functional trajectories and their determinants in contemporary cardiovascular patients in Japan.

Limitations

  • Study population is restricted to patients insured under the NHI or the Medical Care System for the Elderly, excluding employment-based health insurance plans.
  • May limit generalizability to younger CVD patients.
  • Detailed clinical data are collected only at baseline, so longitudinal changes in laboratory values or imaging parameters cannot be systematically assessed.
  • Study population is restricted to patients insured under the NHI or the Medical Care System for the Elderly, which may limit generalizability to younger CVD patients
  • Detailed clinical data are collected only at baseline, so longitudinal changes in laboratory values or imaging parameters cannot be systematically assessed using standardized research protocols

Abstract

Background: As populations age, cardiovascular disease (CVD) increasingly affects functional independence, an issue of growing importance among older adults. However, long-term trajectories of functional decline in patients receiving contemporary CVD care remain poorly characterized, so the Niigata Cardiovascular Disease Registry using Health Insurance Claims (NiCARDIA) was established to address this gap by integrating hospital-based clinical data with administrative datasets through a prefecture-wide data-sharing platform.

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Cite This Study

Fujiki et al. (2026) conducted an observational in Cardiovascular disease (n=8,500). Hospitalization for cardiovascular disease was evaluated on Longitudinal change in functional independence assessed by certified long-term care-need levels. The NiCARDIA registry is a prospective observational cohort designed to evaluate long-term functional trajectories in 8,500 adults hospitalized with cardiovascular disease.

synapsesocial.com/papers/6a9d1df228139818eab20b39https://doi.org/10.1253/circrep.cr-26-0029
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