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September 6, 2026Oncology nursing forum

Impact of Exercise on QOL, Cardiorespiratory Function, and Inflammatory Markers in Breast Cancer Survivors: A Systematic Review and Meta-Analysis

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Authors

WCWenwen ChenMWMingying WeiLZLijuan Zhang

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Overview

Systematic review and meta-analysis demonstrates improved peak oxygen consumption and quality of life in breast cancer survivors, supporting exercise integration into cancer rehabilitation programs.

Key Points

  • Synthesize existing evidence on the effects of exercise on cardiorespiratory function, systemic inflammatory markers, and quality of life among breast cancer survivors.
  • Systematic search of Cochrane Central, Embase, PubMed, and Web of Science from database inception through April 15, 2025.
  • Included 32 studies comprising 1,754 breast cancer survivors, evaluating risk of bias using the Cochrane RoB 2 tool and analyzing data with RevMan 5.4 and Stata 18.0.
  • Exercise significantly improved peak oxygen consumption (WMD = 1.22, p < 0.001), general quality of life (WMD = 6.05, p < 0.001), and breast cancer-specific quality of life (WMD = 5.13, p = 0.045).
  • No statistically significant effects occurred for maximum oxygen consumption, C-reactive protein, interleukin-6, or tumor necrosis factor-alpha (all p > 0.05).

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a9d1e1f28139818eab20c3fhttps://doi.org/10.1188/26.onf.e26535371
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Randomized Controlled Trial of Exercise Training in Postmenopausal Breast Cancer Survivors: Cardiopulmonary and Quality of Life Outcomes2003 · 757 citations
  2. 2IS CARDIORESPIRATORY FITNESS RELATED TO QUALITY OF LIFE IN SURVIVORS OF BREAST CANCER?2006 · 22 citations
  3. 3Mediators of Exercise Effects on HRQoL in Cancer Survivors after Chemotherapy2016 · 30 citations
  4. 4Therapeutic effects of aerobic and resistance exercises for cancer survivors: a systematic review of meta-analyses of clinical trials2018 · 207 citations
  5. 5Effects of Diet and Exercise Lifestyle Interventions on Physical and Psychological Health in Breast Cancer Survivors: A Systematic Review2026